PUMA BH3 (TFA)
PUMA BH3 TFA is a p53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide, acts as a direct activator of Bak, with a Kd of 26 nM[1].
Product Specifications
UNSPSC
12352209
Target
Bcl-2 Family
Type
Peptides
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/puma-bh3-tfa.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@@H](C)CC)C(NCC(N[C@@H](C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCSC)C(N[C@@H](C)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](C)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C.OC(C(F)(F)F)=O.[x]
Molecular Formula
C100H162N34O32S.xC2HF3O2
Molecular Weight
2384.63 (free base)
References & Citations
[1]Lopez A, et al. Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer. Nat Commun. 2022 Mar 7;13 (1) :1199.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
Bak
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC680879-100 1x 100 µL
P57 / KIP2 (KP10), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
RD-MELK-Hu-01 96 Tests
Human Maternal Embryonic Leucine Zipper Kinase (MELK) ELISA Kit
Sign In for Pricing
View Details RD-MELK-Hu-02 48 Tests
Human Maternal Embryonic Leucine Zipper Kinase (MELK) ELISA Kit
Sign In for Pricing
View Details 
AP23709PU-N 100 µg
alpha Defensin 1 (DEFA1) (+Defensin alpha 3) Goat Polyclonal Antibody
Sign In for Pricing
View Details