Anti-Akirin 1 Antibody

Rabbit Polyclonal Antibody specific to Akirin1

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

Anti-Akirin1 Rabbit Polyclonal Antibody

Gene Name

AKIRIN1

NCBI Gene ID

<a href="https://www.ncbi.nlm.nih.gov/gene/?term=AKIRIN1">AKIRIN1</a>

UniProt

Q9H9L7

Cellular Locus

Nucleus

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

N-terminal domain peptide sequence (16 amino acids) derived from human Akirin1 (GenBank accession no. CAI16710).

Target Antigen

Akirin-1

Target

Akirin 1

Clonality

Polyclonal

Isotype

IgG

Type

Antibody

Applications

ELISA, WB

Field of Research

Neuroscience

Purification Method

Purified by peptide immuno-affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium which is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Functions as signal transducer for MSTN during skeletal muscle regeneration and myogenesis. May regulate chemotaxis of both macrophages and myoblasts by reorganising actin cytoskeleton, leading to more efficient lamellipodia formation via a PI3 kinase dependent pathway. {UniProtKB:Q99LF1}.

Additionnal Information

Immunoblotting: use at 2ug/mL <br><br>Positive control: A549 cell lysate.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.

Specificity

This antibody recognizes human, mouse, and rat Akirin1.

Formulation

PBS, pH 7.4.

Buffer pH

pH 7.4

Target Background

Akirin is a recently discovered nuclear protein with an essential function in the Drosophila melanogaster immune deficiency pathway which responds to gram-negative bacterial infection. Akirin is conserved in vertebrates as at least two genes designated akirin1 and akirin2. In mice, akirin2 functions in toll-lie receptor, tumor necrosis factor, and interleukin-1beta signaling pathways downstream of NF-kappaB to induce the transcription of several immune-response genes. In mice, knockout of akirin1 had no obvious phenotypic effects, but knockout of akirin2 was embryonic-lethal.