HIF-1 alpha Recombinant Rabbit Monoclonal Antibody [PSH07-00]

Hypoxia-inducible factor 1-alpha, also known as HIF-1-alpha, is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) that is encoded by the HIF1A gene. The Nobel Prize in Physiology or Medicine 2019 was awarded for the discovery of HIF. HIF1A is a basic helix-loop-helix PAS domain containing protein, and is considered as the master transcriptional regulator of cellular and developmental response to hypoxia. The dysregulation and overexpression of HIF1A by either hypoxia or genetic alternations have been heavily implicated in cancer biology, as well as a number of other pathophysiologies, specifically in areas of vascularization and angiogenesis, energy metabolism, cell survival, and tumor invasion. Two other alternative transcripts encoding different isoforms have been identified.

Product Specifications

CAS Number

9000-83-3

Product Name Alternative

ARNT interacting protein antibody ARNT-interacting protein antibody Basic helix loop helix PAS protein MOP1 antibody Basic-helix-loop-helix-PAS protein MOP1 antibody bHLHe78 antibody Class E basic helix-loop-helix protein 78 antibody HIF 1A antibody HIF 1alpha antibody HIF-1-alpha antibody HIF-1alpha antibody HIF-alpha antibody HIF1 A antibody HIF1 Alpha antibody HIF1 antibody HIF1-alpha antibody HIF1A antibody HIF1A_HUMAN antibody hifla antibody Hypoxia inducible factor 1 alpha antibody Hypoxia inducible factor 1 alpha isoform I.3 antibody Hypoxia inducible factor 1 alpha subunit antibody Hypoxia inducible factor 1 alpha subunit basic helix loop helix transcription factor antibody Hypoxia inducible factor 1, alpha subunit (basic helix loop helix transcription factor) antibody Hypoxia inducible factor1alpha antibody Hypoxia-inducible factor 1-alpha antibody Member of PAS protein 1 antibody Member of PAS superfamily 1 antibody Member of the PAS Superfamily 1 antibody MOP 1 antibody MOP1 antibody PAS domain-containing protein 8 antibody PASD 8 antibody PASD8 antibody

Abbreviation

HIF1A, BHLHE78, MOP1, PASD8

Swiss Prot

Q16665 Human, Q61221 Mouse

Cellular Locus

Cytoplasm, Nucleus, Nucleus speckle.

Host

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthetic peptide within human HIF-1 alpha aa 441-490.

Isotype

IgG

Clone

PSH07-00

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P

Positive Control

HeLa cell lysate, HeLa treated with 0.5mM CoCl2 for 6 hours cell lysate, HepG2 cell lysate, HepG2 treated with 100μM CoCl2 for 4 hours cell lysate, C2C12 cell lysate, C2C12 treated with 100μM CoCl2 for 4 hours cell lysate, HeLa cells treated with 0.5mM CoCl2 for 6 hours, C2C12 cells treated with 200μM CoCl2 for 4 hours.