Isoliquiritigenin

Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza uralensis Fisch., which inhibits aldose reductase with an IC50 of 320 nM. Isoliquiritigenin is a potent inhibitor of influenza virus replication with an EC50 of 24.7 μM.

Product Specifications

CAS Number

[961-29-5]

Product Name Alternative

GU17; ISL; Isoliquiritigen; SJ000286237

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Aldose Reductase; Apoptosis; Autophagy; Influenza Virus

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Autophagy; Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Isoliquiritigenin.html

Purity

98.17

Solubility

DMSO : ≥ 100 mg/mL|Ethanol : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C(O)C=C1O)/C=C/C2=CC=C(O)C=C2

Molecular Formula

C15H12O4

Molecular Weight

256.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Aida K, et al. Isoliquiritigenin: a new aldose reductase inhibitor from glycyrrhizae radix. Planta Med. 1990 Jun;56 (3) :254-8.|[2]Sato Y, et al. Isoliquiritigenin, one of the antispasmodic principles of Glycyrrhiza ularensis roots, acts in the lower part of intestine. Biol Pharm Bull. 2007 Jan;30 (1) :145-9.|[3]Zhang X. Natural antioxidant-isoliquiritigenin ameliorates contractile dysfunction of hypoxic cardiomyocytes via AMPK signaling pathway. Mediators Inflamm. 2013;2013:390890.|[4]Chen X, et al. Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling. J Mol Med (Berl) . 2012 Nov;90 (11) :1311-9.|[5]Traboulsi H, et al. The Flavonoid Isoliquiritigenin Reduces Lung Inflammation and Mouse Morbidity during Influenza Virus Infection. Antimicrob Agents Chemother. 2015 Oct;59 (10) :6317-27.