PIPE-3297
PIPE-3297 (compound 25) is a selective kappa opioid receptor (KOR) agonist, which activates the G-protein signaling with EC50 of 1.1 nM and exhibits low β-arrestin-2 recruitment activity (10%) . PIPE-3297 induces myelination and reveals an anti-inflammatory activity[1].
Product Specifications
UNSPSC
12352005
Target
Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pipe-3297.html
Solubility
10 mM in DMSO
Smiles
OC1=CC=CC(CCN(C2CN(C2)CC3=CC=CC=C3)CC4CCC4)=C1
Molecular Formula
C23H30N2O
Molecular Weight
350.50
References & Citations
[1]Schrader TO, et al., Identification and In Vivo Evaluation of Myelination Agent PIPE-3297, a Selective Kappa Opioid Receptor Agonist Devoid of β-Arrestin-2 Recruitment Efficacy. ACS Chem Neurosci. 2024 Feb 7;15 (3) :685-698.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
κ Opioid Receptor/KOR
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