SP2509
Product Specifications
UNSPSC Description
SP2509 is a potent and selective antagonist of lysine specific demethylase 1 (LSD1) with an IC50 of 13 nM[1].
Target Antigen
Apoptosis; Histone Demethylase
Type
Reference compound
Related Pathways
Apoptosis;Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SP2509.html
Purity
99.90
Solubility
DMSO : ≥ 33 mg/mL
Smiles
O=C(N/N=C(C1=CC(Cl)=CC=C1O)\C)C2=CC=CC(S(=O)(N3CCOCC3)=O)=C2
Molecular Weight
437.90
References & Citations
[1]Fiskus W, et al. Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells. Leukemia. 2014 Nov;28(11):2155-64.|[2]Inui K, et al. Stepwise assembly of functional C-terminal REST/NRSF transcriptional repressor complexes as a drug target. Protein Sci. 2017 Feb 20
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12635/SP2509-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12635/SP2509-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1423715-09-6
Available Sizes
Curated Selection
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