Lin28A Recombinant Rabbit Monoclonal Antibody [JE60-36]
LIN28A is conserved, developmentally regulated RNA binding proteins that inhibit the processing and maturation of the let-7 family of miRNAs. LIN28A is localized to the periendoplasmic reticulum (ER) area and inhibits translation of mRNAs that are destined for the ER, reducing the synthesis of transmembrane proteins, ER or Golgi lumen proteins, and secretory proteins. Overexpression of LIN28A, in conjunction with Oct-4, Sox2, and Nanog, can reprogram human fibroblasts to pluripotent, ES-like cells.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
Lin-28A
Swiss Prot
Q9H9Z2 Human
Cellular Locus
Cytoplasm, Nucleus.
Host
Rabbit
Species Reactivity
Human
Immunogen
Recombinant protein within
Isotype
IgG
Clone
JE60-36
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IF-Cell, FC, IP
Positive Control
NCCIT cell lysate, JAR cell lysate, NCCIT.
Concentration
1 mg/mL
Dilution
WB: 1:1,000 ;IF-Cell: 1:500 ;FC: 1:1,000 ;IP: 1-2μg/sample
Purity
Protein A affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 23 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
Frequently Asked Questions
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