FPR-A14

FPR-A14 is a potent formyl peptide receptor (FPR) agonist. FPR-A14 is a potent activator of neutrophil Ca2+ mobilization and chemotaxis with EC50s of 630 nM and 42 nM, respectively. FPR-A14 induces cell differentiation[1][2].

Product Specifications

CAS Number

[329691-12-5]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Formyl Peptide Receptor (FPR)

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/fpr-a14.html

Purity

98.58

Solubility

DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=CC=C(OCO2)C2=C1)N/N=C/C3=CC=C(OCC4=CC=CC=C4)C(OC)=C3

Molecular Formula

C23H20N2O5

Molecular Weight

404.42

Precautions

H315, H319, H335

References & Citations

[1]Igor A Schepetkin, et al. High-throughput screening for small-molecule activators of neutrophils: identification of novel N-formyl peptide receptor agonists. Mol Pharmacol. 2007 Apr;71 (4) :1061-74.|[2]Peter J G Cussell, et al. The formyl peptide receptor agonist FPRa14 induces differentiation of Neuro2a mouse neuroblastoma cells into multiple distinct morphologies which can be specifically. inhibited with FPR antagonists and FPR knockdown using siRNA. PLoS One. 2019 Jun 6;14 (6) :e0217815.