PF-7006

PF-7006 is an Mps1 kinase inhibitor with a Ki value of 0.27 nM and an IC50 value of 2.5 nM. PF-7006 interferes with cell cycle checkpoints by inhibiting the catalytic activity of Mps1, reducing histone H3 levels, and shortening the duration of mitosis, leading to apoptosis in cancer cells. Combined use of PF-7006 with Palbociclib (HY-50767) increases cancer cell tolerance to PF-7006. PF-7006 can be used for breast cancer research[1].

Product Specifications

CAS Number

[2771955-09-8]

UNSPSC

12352005

Target

Apoptosis; Mitosis; Mps1

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pf-7006.html

Smiles

N#CC1=CNC2=NC(NC3=CC=C(N4CCOCC4)N=C3C)=NC(NC5CCOCC5)=C12

Molecular Formula

C22H26N8O2

Molecular Weight

434.49

References & Citations

[1]Martinez R, et al. Mitotic Checkpoint Kinase Mps1 Has a Role in Normal Physiology which Impacts Clinical Utility. PLoS One. 2015 Sep 23;10 (9) :e0138616.