PF-7006
Product Specifications
UNSPSC Description
PF-7006 is an Mps1 kinase inhibitor with a Ki value of 0.27 nM and an IC50 value of 2.5 nM. PF-7006 interferes with cell cycle checkpoints by inhibiting the catalytic activity of Mps1, reducing histone H3 levels, and shortening the duration of mitosis, leading to apoptosis in cancer cells. Combined use of PF-7006 with Palbociclib (HY-50767) increases cancer cell tolerance to PF-7006. PF-7006 can be used for breast cancer research[1].
Target Antigen
Apoptosis; Mps1
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pf-7006.html
Smiles
N#CC1=CNC2=NC(NC3=CC=C(N4CCOCC4)N=C3C)=NC(NC5CCOCC5)=C12
Molecular Weight
434.49
References & Citations
[1]Martinez R, et al. Mitotic Checkpoint Kinase Mps1 Has a Role in Normal Physiology which Impacts Clinical Utility. PLoS One. 2015 Sep 23;10(9):e0138616.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-164519/PF-7006-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-164519/
Clinical Information
No Development Reported
CAS Number
2771955-09-8
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