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Val-Cit-PAB-Exatecan (TFA)

Val-Cit-PAB-Exatecan (Val-Cit-PAB-DX8951) TFA is a agent-linker conjugate for ADC. Val-Cit-PAB-Exatecan TFA is composed of a DNA topoisomerase I DX-8951 (HY-13631) and a cathepsin cleavable ADC linker[1].

Product Specifications

CAS Number

[2928571-44-0]

Product Name Alternative

Val-Cit-PAB-DX8951 (TFA)

UNSPSC

12352203

Target

Drug-Linker Conjugates for ADC; Topoisomerase

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/val-cit-pab-exatecan-tfa.html

Purity

99.73

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C)[C@H](N)C(N[C@@H](CCCNC(N)=O)C(NC(C=C1)=CC=C1COC(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O)=O)=O.O=C(O)C(F)(F)F

Molecular Formula

C45H50F4N8O11

Molecular Weight

954.92

References & Citations

[1]Thomas A, et al. Antibody-drug conjugates for cancer therapy. Lancet Oncol. 2016 Jun;17 (6) :e254-e262.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

ADC Related

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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