Hispidin

Hispidin, a PKC inhibitor and a phenolic compound can be found in Phellinus linteus, has been shown to possess strong anti-oxidant, anti-cancer, anti-diabetic, and anti-dementia properties[1][2][3][4][5][6][7].

Product Specifications

CAS Number

[555-55-5]

UNSPSC

12352005

Hazard Statement

H317, H319

Target

Akt; Endogenous Metabolite; ERK; Ferroptosis; GSK-3; JAK; JNK; Keap1-Nrf2; p38 MAPK; PKC; Reactive Oxygen Species (ROS) ; STAT

Type

Natural Products

Related Pathways

Apoptosis; Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt; TGF-beta/Smad

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/hispidin.html

Purity

99.85

Solubility

DMSO : 19.23 mg/mL (ultrasonic)

Smiles

O=C1C=C(O)C=C(/C=C/C2=CC=C(O)C(O)=C2)O1

Molecular Formula

C13H10O5

Molecular Weight

246.22

Precautions

H317, H319

References & Citations

[1]Kim DE, et al. The protective effect of hispidin against hydrogen peroxide-induced apoptosis in H9c2 cardiomyoblast cells through Akt/GSK-3β and ERK1/2 signaling pathway. Exp Cell Res. 2014 Oct 1;327 (2) :264-75.|[2]Wu F, et al. Hispidin Inhibits Ferroptosis Induced by High Glucose via the miR-15b-5p/GLS2 Axis in Pancreatic Beta Cells. Evid Based Complement Alternat Med. 2023 Feb 21;2023:9428241.|[3]Han Y H, et al. Anti-inflammatory effect of hispidin on LPS induced macrophage inflammation through MAPK and JAK1/STAT3 signaling pathways[J]. Applied Biological Chemistry, 2020, 63: 1-9.|[4]Lai MC, et al. Hispidin in the Medicinal Fungus Protects Dopaminergic Neurons from JNK Activation-Regulated Mitochondrial-Dependent Apoptosis in an MPP+-Induced In Vitro Model of Parkinson's Disease. Nutrients. 2023 Jan 20;15 (3) :549.|[5]Kim DE, et al. The protective effect of hispidin against hydrogen peroxide-induced apoptosis in H9c2 cardiomyoblast cells through Akt/GSK-3β and ERK1/2 signaling pathway. Exp Cell Res. 2014 Oct 1;327 (2) :264-75.|[6]Huang SY, et al. The Protective Effect of Hispidin against Hydrogen Peroxide-Induced Oxidative Stress in ARPE-19 Cells via Nrf2 Signaling Pathway. Biomolecules. 2019 Aug 19;9 (8) :380.|[7]Liu YS, et al. Exploring the Wound Healing Potential of Hispidin. Nutrients. 2024 Sep 19;16 (18) :3161.