What is the catalog number for Hispidin?

The catalog number for Hispidin is HY-100618.

What sizes are available for Hispidin?

Hispidin is available in the following size(s): 5 mg, 10 mM - 1 mL, 10 mg, 25 mg, 50 mg, 100 mg.

How many pack sizes does Hispidin come in?

Hispidin is available in 6 different pack sizes.

Is Hispidin in stock?

Hispidin is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Hispidin?

Hispidin is manufactured by QuantiMol.

What is the estimated delivery time for Hispidin?

Estimated delivery time for Hispidin is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Hispidin?

The safety data sheet for Hispidin is available here: http://file.medchemexpress.com/batch_PDF/HY-100618/Hispidin-SDS-MedChemExpress.pdf.

Hispidin

Hispidin, a PKC inhibitor and a phenolic compound can be found in Phellinus linteus, has been shown to possess strong anti-oxidant, anti-cancer, anti-diabetic, and anti-dementia properties[1][2][3][4][5][6][7].

Product Specifications

CAS Number

555-55-5

UNSPSC

12352005

Hazard Statement

H317, H319

Target

Akt; Endogenous Metabolite; ERK; Ferroptosis; GSK-3; JAK; JNK; Keap1-Nrf2; p38 MAPK; PKC; Reactive Oxygen Species (ROS) ; STAT

Type

Natural Products

Related Pathways

Apoptosis; Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt; TGF-beta/Smad

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/hispidin.html

Purity

99.85

Solubility

DMSO : 19.23 mg/mL (ultrasonic)

Smiles

O=C1C=C(O)C=C(/C=C/C2=CC=C(O)C(O)=C2)O1

Molecular Formula

C13H10O5

Molecular Weight

246.22

Precautions

H317, H319

References & Citations

[1]Kim DE, et al. The protective effect of hispidin against hydrogen peroxide-induced apoptosis in H9c2 cardiomyoblast cells through Akt/GSK-3β and ERK1/2 signaling pathway. Exp Cell Res. 2014 Oct 1;327 (2) :264-75.|[2]Wu F, et al. Hispidin Inhibits Ferroptosis Induced by High Glucose via the miR-15b-5p/GLS2 Axis in Pancreatic Beta Cells. Evid Based Complement Alternat Med. 2023 Feb 21;2023:9428241.|[3]Han Y H, et al. Anti-inflammatory effect of hispidin on LPS induced macrophage inflammation through MAPK and JAK1/STAT3 signaling pathways[J]. Applied Biological Chemistry, 2020, 63: 1-9.|[4]Lai MC, et al. Hispidin in the Medicinal Fungus Protects Dopaminergic Neurons from JNK Activation-Regulated Mitochondrial-Dependent Apoptosis in an MPP+-Induced In Vitro Model of Parkinson's Disease. Nutrients. 2023 Jan 20;15 (3) :549.|[5]Kim DE, et al. The protective effect of hispidin against hydrogen peroxide-induced apoptosis in H9c2 cardiomyoblast cells through Akt/GSK-3β and ERK1/2 signaling pathway. Exp Cell Res. 2014 Oct 1;327 (2) :264-75.|[6]Huang SY, et al. The Protective Effect of Hispidin against Hydrogen Peroxide-Induced Oxidative Stress in ARPE-19 Cells via Nrf2 Signaling Pathway. Biomolecules. 2019 Aug 19;9 (8) :380.|[7]Liu YS, et al. Exploring the Wound Healing Potential of Hispidin. Nutrients. 2024 Sep 19;16 (18) :3161.