Sacubitrilat
Sacubitrilat (Desethyl Sacubitril) is an active neprilysin (NEP) inhibitor.
Product Specifications
CAS Number
[149709-44-4]
Product Name Alternative
Desethyl Sacubitril; LBQ-657
UNSPSC
12352005
Hazard Statement
H336, H372
Target
Neprilysin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Sacubitrilat.html
Purity
99.73
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
[H]N(C(CCC(O)=O)=O)[C@H](CC(C=C1)=CC=C1C2=CC=CC=C2)C[C@H](C(O)=O)C
Molecular Formula
C22H25NO5
Molecular Weight
383.44
Precautions
H336, H372
References & Citations
[1]Schiering N, et al. Structure of neprilysin in complex with the active metabolite of sacubitril. Sci Rep. 2016 Jun 15;6:27909.|[2]Langenickel TH, et al. Single therapeutic and supratherapeutic doses of sacubitril/valsartan (LCZ696) do not affect cardiac repolarization. Eur J Clin Pharmacol. 2016 Aug;72 (8) :917-24.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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