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TLR4-IN-1

TLR4-IN-1 (compound 3k) inhibits the cell viability of RAW264.7 with an IC50 of 1.02 μM. TLR4-IN-1 inhibits the release of cytokine TNF-α, IL-1β and IL-6, and exhibits anti-inflammatory efficacy in rats rheumatoid arthritis models[1].

Product Specifications

CAS Number

[2617578-93-3]

UNSPSC

12352211

Target

Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tlr4-in-1.html

Smiles

O=C1C(C(C)CC1C(CC(C)=O)=O)=O

Molecular Formula

C10H12O4

Molecular Weight

196.20

References & Citations

[1]Zhou S, et al., Design, Synthesis, and Antirheumatoid Arthritis Mechanism of TLR4 Inhibitors. ACS Omega. 2024 Aug 14;9 (34) :36232-36241.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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