TLR4-IN-1
TLR4-IN-1 (compound 3k) inhibits the cell viability of RAW264.7 with an IC50 of 1.02 μM. TLR4-IN-1 inhibits the release of cytokine TNF-α, IL-1β and IL-6, and exhibits anti-inflammatory efficacy in rats rheumatoid arthritis models[1].
Product Specifications
CAS Number
[2617578-93-3]
UNSPSC
12352211
Target
Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tlr4-in-1.html
Smiles
O=C1C(C(C)CC1C(CC(C)=O)=O)=O
Molecular Formula
C10H12O4
Molecular Weight
196.20
References & Citations
[1]Zhou S, et al., Design, Synthesis, and Antirheumatoid Arthritis Mechanism of TLR4 Inhibitors. ACS Omega. 2024 Aug 14;9 (34) :36232-36241.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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