NTRC-844

NTRC-844 (compound 8) is a selective antagonist of neurotensin receptor type 2 (NTS2), with the EC50 of 238 nM. NTRC-844 plays an important role in analgesic animal research[1].

Product Specifications

CAS Number

[1811503-67-9]

UNSPSC

12352005

Target

Neurotensin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ntrc-844.html

Purity

95.60

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=NN(C(C=C2)=CC=C2F)C(C(C=CC=C3)=C3OC)=C1)NC4([C@H]5C[C@H](C6)C[C@@H]4C[C@H]6C5)C(O)=O

Molecular Formula

C28H28FN3O4

Molecular Weight

489.54

References & Citations

[1]James B Thomas, et al. Identification of 2- ({[1- (4-Fluorophenyl) -5- (2-methoxyphenyl) -1H-pyrazol-3-yl]carbonyl}amino) tricyclo[3.3.1.13,7]decane-2-carboxylic Acid (NTRC-844) as a Selective Antagonist for the Rat Neurotensin Receptor Type 2. ACS Chem Neurosci. 2016 Sep 21;7 (9) :1225-31.