Tauro-β-muricholic acid (sodium)
Tauro-β-muricholic Acid sodium (T-βMCA sodium), a endogenous metabolite, is a competitive and reversible farnesoid X receptor (FXR) antagonist, with an IC50 of 40 μM[1][2][3].
Product Specifications
CAS Number
145022-92-0
Product Name Alternative
T-βMCA (sodium)
UNSPSC
12352211
Hazard Statement
H315, H319, H335
Target
FXR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tauro-β-muricholic-acid-sodium.html
Concentration
10mM
Purity
99.54
Solubility
DMSO : 10 mg/mL (ultrasonic; warming)
Smiles
C[C@@]([C@]1([H])[C@H](O)[C@@H]2O)(CC[C@@H](O)C1)[C@]3([H])[C@]2([H])[C@@](CC[C@]4([H])[C@H](C)CCC(NCCS(=O)(O[Na])=O)=O)([H])[C@]4(C)CC3
Molecular Formula
C26H44NNaO7S
Molecular Weight
537.68
Precautions
H315, H319, H335
References & Citations
[1]Sayin SI, et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab. 2013 Feb 5;17 (2) :225-35.|[2]Wahlström A, et al. Induction of farnesoid X receptor signaling in germ-free mice colonized with a human microbiota. J Lipid Res. 2017 Feb;58 (2) :412-419.|[3]Fu T, et al. FXR Regulates Intestinal Cancer Stem Cell Proliferation. Cell. 2019 Feb 21;176 (5) :1098-1112.e18.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Cell Host Microbe. 2024 Feb 14;32 (2) :191-208.e9.|J Pharm Biomed Anal. 2025 Jul 15:259:116760.|World J Gastrointest Oncol. 2025 Aug 15;17 (8) :107453.|Cell. 2025 Aug 21;188 (17) :4530-4548.e25.
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