CENP-E-IN-2

CENP-E-IN-2 (compound 3) is a photoswitchable CENP-E inhibitor, with the pIC50 of 6.82 without light illumination and 5.85 with 365 nm light illumination. CENP-E-IN-2 has antitumor activity[1].

Product Specifications

UNSPSC

12352005

Target

Kinesin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cenp-e-in-2.html

Smiles

ClC1=C(OC(C)C)C=CC(C(N[C@H](C(NC)=O)CC2=CC=C(/N=N/C3=C(C)N(CCO)N=C3C)C=C2)=O)=C1

Molecular Formula

C27H33ClN6O4

Molecular Weight

541.04

References & Citations

[1]Kazuya Matsuo, et al. A chemical platform for the efficient screening of arylazopyrazole-based photoswitchable CENP-E inhibitors using mild cyclization reactions. Bioorg Med Chem Lett. 2024 Jul 17:111:129892.