Selinexor (Standard)
Selinexor (Standard) is the analytical standard of Selinexor. This product is intended for research and analytical applications. Selinexor (KPT-330), analog of KPT-185, is an orally bioavailable and selective CRM1 inhibitor[1][2].
Product Specifications
CAS Number
1393477-72-9
Product Name Alternative
KPT-330 (Standard)
UNSPSC
12352005
Target
CRM1; Reference Standards
Type
Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/selinexor-standard.html
Smiles
O=C(NNC1=NC=CN=C1)/C=C\N2N=C(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)N=C2
Molecular Formula
C17H11F6N7O
Molecular Weight
443.31
References & Citations
[1]Etchin J, et al. KPT-330 inhibitor of CRM1 (XPO1) -mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia. Br J Haematol. 2013 Apr;161 (1) :117-27.|[2]Tai YT, et al. CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications. Leukemia. 2014 Jan;28 (1) :155-65.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
Frequently Asked Questions
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