Chromeceptin
Chromeceptin (94G6) is an IGF signaling pathway inhibitor. Chromeceptin suppresses IGF2 expression at mRNA and protein levels in hepatocyte and HCC cells. Chromeceptin inhibits the phosphorylation levels of AKT and mTOR[1].
Product Specifications
CAS Number
331859-86-0
Product Name Alternative
94G6
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Akt; IGF-1R; mTOR
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/chromeceptin.html
Purity
99.80
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
N#CC1=C(N)OC2=CC(N(C)C)=CC=C2C1C3=CC=CC(C(F)(F)F)=C3
Molecular Formula
C19H16F3N3O
Molecular Weight
359.35
Precautions
H315, H319
References & Citations
[1]Seol HS, et al. Loss of miR-100 and miR-125b results in cancer stem cell properties through IGF2 upregulation in hepatocellular carcinoma. Sci Rep. 2020 Dec 8;10 (1) :21412.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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