C21

Product Specifications

CAS Number

[1229236-78-5]

UNSPSC Description

C21 is a potent, irreversible, and selective PRMT1 inhibitor with an IC50 of 1.8 μM. C21 inhibits PRMT6 with an IC50 of 8.8 μM[1].

Target Antigen

Histone Methyltransferase

Type

Peptides

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/c21.html

Solubility

10 mM in DMSO

Smiles

CC(C)[C@@H](C(O)=O)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](C)NC(CNC(CNC([C@H](CCCCN)NC(CNC([C@H](CC(C)C)NC(CNC([C@H](CCCCN)NC(CNC(CNC([C@H](CCCCN)NC(CNC([C@H](CCCNC(CCl)=N)NC(CNC([C@H](CO)NC(C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC1=CN=CN1)=O)=O)=O

Molecular Weight

2166.92

References & Citations

[1]Obiamaka Obianyo, et al. A chloroacetamidine-based inactivator of protein arginine methyltransferase 1: design, synthesis, and in vitro and in vivo evaluation. Chembiochem. 2010 Jun 14;11(9):1219-23.