KME-2780
KME-2780 is the orally active inhibitor for IRAK1 and IRAK4 with IC50s of 19 nM and 0.5 nM. KME-2780 can be used for research of dysregulation of innate immune signaling and hematologic malignancies[1].
Product Specifications
CAS Number
[2968466-26-2]
UNSPSC
12352005
Target
Apoptosis; IRAK
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kme-2780.html
Purity
98.94
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1(CC1)C2=CN3C(C4=CC=CC(N[C@H]5CCNC5)=N4)=CN=C3C=C2
Molecular Formula
C20H23N5
Molecular Weight
333.43
References & Citations
[1]Bennett J, et al. Paralog-specific signaling by IRAK1/4 maintains MyD88-independent functions in MDS/AML. Blood. 2023 Sep 14;142 (11) :989-1007.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
IRAK1; IRAK4
Available Sizes
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