MitoB-d15 (bromide)

MitoB-d15 (bromide) is deuterium labeled MitoB (bromide) . MitoB bromide is an exomarker of mitochondrial hydrogen peroxide. MitoB bromide is a mitochondria-targeted ratiometric probe, and can be used to measure levels of one major ROS, hydrogen peroxide, within living animals[1][2].

Product Specifications

UNSPSC

12352005

Target

Isotope-Labeled Compounds; Reactive Oxygen Species (ROS)

Type

Isotope-Labeled Compounds

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

Field of Research

Inflammation/Immunology

Smiles

OB(C1=CC=CC(C[P+](C2=C(C([2H])=C(C([2H])=C2[2H])[2H])[2H])(C3=C(C([2H])=C(C([2H])=C3[2H])[2H])[2H])C4=C(C([2H])=C(C([2H])=C4[2H])[2H])[2H])=C1)O.[Br-]

Molecular Formula

C25H8D15BBrO2P

Molecular Weight

492.23

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Salin K, et al. Using the MitoB method to assess levels of reactive oxygen species in ecological studies of oxidative stress. Sci Rep. 2017 Jan 24;7:41228.|[3]Cochemé HM, et al. Using the mitochondria-targeted ratiometric mass spectrometry probe MitoB to measure H2O2 in living Drosophila. Nat Protoc. 2012 Apr 19;7 (5) :946-58.