Gotistobart

Gotistobart (ONC-392) is a humanized anti-CTLA-4 antibody that confers immunotherapeutic effect by selective depletion of regulatory T cells (Treg) in the tumor microenvironment[1].

Product Specifications

CAS Number

[2226344-78-9]

Product Name Alternative

ONC-392; BNT 316

UNSPSC

12352203

Target

CTLA-4

Type

Inhibitory Antibodies

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gotistobart.html

Purity

99.0

Solubility

10 mM in DMSO

Smiles

[Gotistobart]

Molecular Weight

(146.22 kDa)

References & Citations

[1]Kai He, Safety and clinical activity of target-preserving anti-CTLA-4 antibody ONC-392 as monotherapy in NSCLC patients who progressed on PD (L) 1-targeted immunotherapy. Journal of Clinical Oncology, Volume 41, Issue 16_suppl.