Gotistobart
Product Specifications
UNSPSC Description
Gotistobart (ONC-392) is a humanized anti-CTLA-4 antibody that confers immunotherapeutic effect by selective depletion of regulatory T cells (Treg) in the tumor microenvironment[1].
Target Antigen
CTLA-4
Type
Inhibitory Antibodies
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gotistobart.html
Purity
98.00
Solubility
10 mM in DMSO
Smiles
[Gotistobart]
References & Citations
[1]Kai He,Safety and clinical activity of target-preserving anti-CTLA-4 antibody ONC-392 as monotherapy in NSCLC patients who progressed on PD(L)1-targeted immunotherapy. Journal of Clinical Oncology, Volume 41, Issue 16_suppl.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P990042/Gotistobart-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P990042/Gotistobart-SDS-MedChemExpress.pdf
Clinical Information
Phase 3
CAS Number
2226344-78-9
Available Sizes
Curated Selection
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