Gotistobart
Gotistobart (ONC-392) is a humanized anti-CTLA-4 antibody that confers immunotherapeutic effect by selective depletion of regulatory T cells (Treg) in the tumor microenvironment[1].
Product Specifications
CAS Number
[2226344-78-9]
Product Name Alternative
ONC-392; BNT 316
UNSPSC
12352203
Target
CTLA-4
Type
Inhibitory Antibodies
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gotistobart.html
Purity
99.0
Solubility
10 mM in DMSO
Smiles
[Gotistobart]
Molecular Weight
(146.22 kDa)
References & Citations
[1]Kai He, Safety and clinical activity of target-preserving anti-CTLA-4 antibody ONC-392 as monotherapy in NSCLC patients who progressed on PD (L) 1-targeted immunotherapy. Journal of Clinical Oncology, Volume 41, Issue 16_suppl.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 3
Available Sizes
Curated Selection
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