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C1s-IN-1

C1s-IN-1 (compound A1) is a selective and competitive inhibitor of C1s. C1s-IN-1 binds directly to C1s with a Kd of 9.8 μM[1].

Product Specifications

CAS Number

1016866-61-7

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Complement System

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/c1s-in-1.html

Solubility

10 mM in DMSO

Smiles

NC(=N)C1C=NC(=CC=1)N2CCN(CC2)C3=CC=CC=C3

Molecular Formula

C16H19N5

Molecular Weight

281.36

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Xu X, et al. Inhibition of the C1s Protease and the Classical Complement Pathway by 6- (4-Phenylpiperazin-1-yl) Pyridine-3-Carboximidamide and Chemical Analogs. J Immunol. 2024 Feb 15;212 (4) :689-701.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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