Dihydrocapsaicin-d3
Dihydrocapsaicin-d3 is the deuterium labeled Dihydrocapsaicin (HY-N0361) [1]. Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat[2][3][4].
Product Specifications
CAS Number
[1330261-21-6]
UNSPSC
12352005
Hazard Statement
H301, H315, H319, H335, H341
Target
Akt; Apoptosis; Bcl-2 Family; Caspase; Isotope-Labeled Compounds; PI3K; Reactive Oxygen Species (ROS) ; TRP Channel
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; Others; PI3K/Akt/mTOR
Field of Research
Others
Solubility
10 mM in DMSO
Smiles
CC(C)CCCCCCC(NCC1=CC=C(O)C(OC([2H])([2H])[2H])=C1)=O
Molecular Formula
C18H26D3NO3
Molecular Weight
310.45
Precautions
H301, H315, H319, H335, H341
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
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