PI3K/Akt/mTOR-IN-2
Product Specifications
UNSPSC Description
PI3K/Akt/mTOR-IN-2 is a PI3K/AKT/mTOR pathway inhibitor. PI3K/Akt/mTOR-IN-2 possess anti-cancer effects and selectivity against MDA-MB-231 cells with IC50 value of 2.29 μM. PI3K/Akt/mTOR-IN-2 can induce cancer cell cycle arrest and apoptosis[1].
Target Antigen
Akt; Apoptosis; mTOR; PI3K
Type
Reference compound
Related Pathways
Apoptosis;PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pi3k-akt-mtor-in-2.html
Solubility
DMSO : ≥ 100 mg/mL
Smiles
FC1=CC(F)=CC(C2OCCC3=C2NC4=C3C=CC=C4)=C1
Molecular Weight
285.29
References & Citations
[1]Qin J, Sun X, Ma Y, et al. Design, synthesis and biological evaluation of novel 1,3,4,9-tetrahydropyrano[3,4-b]indoles as potential treatment of triple negative breast cancer by suppressing PI3K/AKT/mTOR pathway [published online ahead of print, 2021 Dec 31]. Bioorg Med Chem. 2021;55:116594.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-146751/PI3K-Akt-mTOR-IN-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-146751/PI3K-Akt-mTOR-IN-2-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2757804-89-8
Available Sizes
Curated Selection
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