PI3K/Akt/mTOR-IN-2

PI3K/Akt/mTOR-IN-2 is a PI3K/AKT/mTOR pathway inhibitor. PI3K/Akt/mTOR-IN-2 possess anti-cancer effects and selectivity against MDA-MB-231 cells with IC50 value of 2.29 μM. PI3K/Akt/mTOR-IN-2 can induce cancer cell cycle arrest and apoptosis[1].

Product Specifications

CAS Number

[2757804-89-8]

UNSPSC

12352005

Target

Akt; Apoptosis; mTOR; PI3K

Type

Reference compound

Related Pathways

Apoptosis; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pi3k-akt-mtor-in-2.html

Purity

99.93

Solubility

DMSO : ≥ 100 mg/mL

Smiles

FC1=CC(F)=CC(C2OCCC3=C2NC4=C3C=CC=C4)=C1

Molecular Formula

C17H13F2NO

Molecular Weight

285.29

References & Citations

[1]Qin J, Sun X, Ma Y, et al. Design, synthesis and biological evaluation of novel 1,3,4,9-tetrahydropyrano[3,4-b]indoles as potential treatment of triple negative breast cancer by suppressing PI3K/AKT/mTOR pathway [published online ahead of print, 2021 Dec 31]. Bioorg Med Chem. 2021;55:116594.