Trans-Pralsetinib
Trans-Pralsetinib (trans-BLU-667) is a rearranged during transfection (RET) inhibitor extracted from patent US20170121312A1, Compound Example 129[1].
Product Specifications
CAS Number
[2097132-93-7]
Product Name Alternative
Trans-BLU-667
UNSPSC
12352005
Hazard Statement
H301, H311, H331
Target
RET
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cis-pralsetinib.html
Purity
98.06
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@]1(OC)CC[C@H](C2=NC(NC3=NNC(C)=C3)=CC(C)=N2)CC1)N[C@H](C4=CC=C(N5N=CC(F)=C5)N=C4)C
Molecular Formula
C27H32FN9O2
Molecular Weight
533.60
Precautions
H301, H311, H331
References & Citations
[1]Jason D. Brubaker, et al. Inhibitors of ret. US20170121312A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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