Regorafenib N-oxide and N-desmethyl (M5)

Regorafenib N-oxide and N-desmethyl (M5) (N-Desmethyl regorafenib N-oxide) is an active metabolite of Sorafenib (HY-10201) and can be metabolized by CYP3A4[1].

Product Specifications

CAS Number

[835621-12-0]

Product Name Alternative

N-Desmethyl regorafenib N-oxide

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

C-Kit; Drug Metabolite; Raf; VEGFR

Type

Reference compound

Related Pathways

MAPK/ERK Pathway; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/regorafenib-n-oxide-and-n-desmethyl-m5.html

Smiles

O=C(C1=CC(OC2=CC=C(NC(NC3=CC=C(Cl)C(C(F)(F)F)=C3)=O)C(F)=C2)=CC=[N+]1[O-])N

Molecular Formula

C20H13ClF4N4O4

Molecular Weight

484.79

Precautions

H302, H315, H319, H335

References & Citations

[1]Ying-Hui Li, et al. Functional characterization of 27 CYP3A4 protein variants to metabolize regorafenib in vitro. Basic Clin Pharmacol Toxicol. 2019 Oct;125 (4) :337-344.