SCH 546738
SCH 546738 is a potent, orally active and non-competitive CXCR3 antagonist, the affinity constant (Ki) of SCH 546738 binding to human CXCR3 receptor is determined to be 0.4 nM in multiple experiments.
Product Specifications
CAS Number
[906805-42-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CXCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Endocrinology
Assay Protocol
https://www.medchemexpress.com/SCH-546738.html
Purity
98.71
Solubility
1 M HCl : 5 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : 2.5 mg/mL (ultrasonic)
Smiles
O=C(N)C1=NC(Cl)=C(N2CCN(C3CCN(CC4=CC=C(Cl)C=C4)CC3)[C@@H](CC)C2)N=C1N
Molecular Formula
C23H31Cl2N7O
Molecular Weight
492.44
Precautions
H302, H315, H319, H335
References & Citations
+
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CXCR3
Available Sizes
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