PRMT5-IN-34
PRMT5-IN-34 (Compound C) is an inhibitor of MTA-cooperative Protein arginine methyltransferase 5 (PRMT5/MAT) [1].
Product Specifications
CAS Number
2918814-97-6
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/prmt5-in-34.html
Solubility
10 mM in DMSO
Smiles
CC#CCN1CC[C@]2(C3=CC=C(C=C3C(N2CC4=CC5=C(N4)C=C(C(N)=N5)F)=O)F)C1=O
Molecular Formula
C23H19F2N5O2
Molecular Weight
435.43
References & Citations
[1]James T et al. Methylthioadenosine (MTA) -cooperative protein arginine methyltransferase 5 (PRMT5) inhibitors for use in the treatment of cancer that is wild type MTAP gene silenced. World Intellectual Property Organization, WO2024038004 A1 2024-02-22
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PRMT5
Frequently Asked Questions
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