PRMT5-IN-34

PRMT5-IN-34 (Compound C) is an inhibitor of MTA-cooperative Protein arginine methyltransferase 5 (PRMT5/MAT) [1].

Product Specifications

CAS Number

[2918814-97-6]

UNSPSC

12352005

Target

Histone Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/prmt5-in-34.html

Solubility

10 mM in DMSO

Smiles

CC#CCN1CC[C@]2(C3=CC=C(C=C3C(N2CC4=CC5=C(N4)C=C(C(N)=N5)F)=O)F)C1=O

Molecular Formula

C23H19F2N5O2

Molecular Weight

435.43

References & Citations

[1]James T et al. Methylthioadenosine (MTA) -cooperative protein arginine methyltransferase 5 (PRMT5) inhibitors for use in the treatment of cancer that is wild type MTAP gene silenced. World Intellectual Property Organization, WO2024038004 A1 2024-02-22