VAV1 degrader-2

VAV1 degrader-2 (Example 176) is a molecular glue degrader based on targeting VAV 1 with a DC50 of 4.41 nM. VAV1 degrader-2 can be used in the study of inflammatory and autoimmune diseases[1].

Product Specifications

CAS Number

[3050683-29-6]

UNSPSC

12352101

Target

Molecular Glues

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/vav1-degrader-2.html

Purity

98.15

Solubility

DMSO : 20 mg/mL (ultrasonic)

Smiles

ClC1=C(C2CCC(NC2=O)=O)C=CC=C1C3=CC=C(CC4=NN(C)C=C4)C=C3

Molecular Formula

C22H20ClN3O2

Molecular Weight

393.87

References & Citations

[1]Laura Ann Mcallister, et al. Targeted degradation of vav1. WO2024151547A1. 2024-01-08

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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