GSK 2830371

GSK 2830371 is a highly selective Wip1 phosphatase inhibitor with IC50 of 6 nM.

Product Specifications

CAS Number

[1404456-53-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Phosphatase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gsk-2830371.html

Purity

99.70

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

ClC1=CN=C(C)C(NCC2=CC=C(C(N[C@@H](CC3CCCC3)C(NC4CC4)=O)=O)S2)=C1

Molecular Formula

C23H29ClN4O2S

Molecular Weight

461.02

Precautions

H302, H315, H319, H335

References & Citations

[1]Gilmartin AG, et al. Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction. Nat Chem Biol. 2014 Mar;10 (3) :181-7.|[2]Esfandiari A, et al. Chemical Inhibition of Wild-Type p53-Induced Phosphatase 1 (WIP1/PPM1D) by GSK2830371 Potentiates the Sensitivity to MDM2 Inhibitors in a p53-Dependent Manner. Mol Cancer Ther. 2016 Mar;15 (3) :379-91.