NAAA-IN-1
NAAA-IN-1 (Compound 1) is a potent and selective inhibitor of NAAA with an IC50 of 7 nM. NAAA is a cysteine amidase which preferentially hydrolyzes the endogenous biolipids palmitoylethanolamide (PEA) and oleoylethanolamide (OEA) . NAAA-IN-1 has the potential for the research of inflammation and pain[1].
Product Specifications
CAS Number
1439366-66-1
UNSPSC
12352005
Target
Ceramidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/naaa-in-1.html
Purity
99.65
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@@H]1OC([C@@H]1NC(OCC2=CC=C(C=C2)C3=CC=CC=C3)=O)=O
Molecular Formula
C18H17NO4
Molecular Weight
311.33
References & Citations
[1]Malamas MS, et al. Design and synthesis of cyanamides as potent and selective N-acylethanolamine acid amidase inhibitors. Bioorg Med Chem. 2020 Jan 1;28 (1) :115195.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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