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NAAA-IN-1

NAAA-IN-1 (Compound 1) is a potent and selective inhibitor of NAAA with an IC50 of 7 nM. NAAA is a cysteine amidase which preferentially hydrolyzes the endogenous biolipids palmitoylethanolamide (PEA) and oleoylethanolamide (OEA) . NAAA-IN-1 has the potential for the research of inflammation and pain[1].

Product Specifications

CAS Number

1439366-66-1

UNSPSC

12352005

Target

Ceramidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/naaa-in-1.html

Purity

99.65

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@H]1OC([C@@H]1NC(OCC2=CC=C(C=C2)C3=CC=CC=C3)=O)=O

Molecular Formula

C18H17NO4

Molecular Weight

311.33

References & Citations

[1]Malamas MS, et al. Design and synthesis of cyanamides as potent and selective N-acylethanolamine acid amidase inhibitors. Bioorg Med Chem. 2020 Jan 1;28 (1) :115195.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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