PSAP Polyclonal Antibody
Product Specifications
Background
Prosaposin behaves as a myelinotrophic and neurotrophic factor, whose effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.By similarity Saposins are specific low-molecular mass non-enzymic proteins and participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases. The Prosaposin gets cleaved into 5 chains, Saposin A, B, B-Val, C and D. It also contains several disulfide bonds as well as glycosylation sites.
Abbreviation
PSAP
UniProt
P07602
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Human PSAP protein expressed by Mammalian
Target
GLBA; prosaposin; SAP1; SAP; PSAP; GLBA; SAP1; proactivator polypeptide; prosaposin; SAP1p; PSA
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Signal Transduction; Metabolism
Purification
Antigen Affinity Purification
Concentration
1 mg/mL
Dilution
WB 1:1000-1:2000; IHC 1:500-1:1000
Buffer
PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. Protected from prolonged exposure to light.
Calculated Molecular Weight
58 kDa
Observed Molecular Weight
60-80 kDa
Isotype
IgG
Available Sizes
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