BMH-21

BMH-21 is a first-in-class DNA intercalator which inhibits RNA polymerase I (Pol I) transcription. BMH-21 possesses anticancer activity[1][2].

Product Specifications

CAS Number

[896705-16-1]

UNSPSC

12352005

Hazard Statement

H302

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/BMH-21.html

Purity

99.25

Solubility

DMSO : 1 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=CN2C1=NC3=C(C=C4C(C=CC=C4)=C3)C2=O)NCCN(C)C

Molecular Formula

C21H20N4O2

Molecular Weight

360.41

Precautions

H302

References & Citations

[1]Colis L, et al. DNA intercalator BMH-21 inhibits RNA polymerase I independent of DNA damage response. Oncotarget. 2014 Jun 30;5 (12) :4361-9.|[2]Karita Peltonen, et al. A Targeting Modality for Destruction of RNA Polymerase I that Possesses Anticancer Activity. Cancer Cell. 2014 Jan 13; 25 (1) : 77–90.