2B- (SP)

2B- (SP) is a eIF2B-based substrate for glycogen synthase kinase-3 (GSK-3) . 2B- (SP) is readily phosphorylated by both the α and β isoforms of GSK-3[1].

Product Specifications

CAS Number

[186901-17-7]

UNSPSC

12352209

Target

GSK-3

Type

Peptides

Related Pathways

PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/2b-sp.html

Solubility

10 mM in DMSO

Smiles

N=C(N)NCCC[C@H](N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(NCC(N[C@@H](COP(O)(O)=O)C(N1[C@@H](CCC1)C(N[C@@H](CCC(N)=O)C(N[C@H](C(O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C71H123N26O29P

Molecular Weight

1835.87

References & Citations

[1]G I Welsh, et al. Peptide substrates suitable for assaying glycogen synthase kinase-3 in crude cell extracts.Anal Biochem. 1997 Jan 1;244 (1) :16-21.