BI-749327

BI-749327 is a potent, high selectivity and orally bioavailable TRPC6 antagonist, with IC50s of 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6, respectively. BI-749327 is 85-fold more selective for mouse TRPC6 than TRPC3 and 42-fold versus TRPC7[1].

Product Specifications

CAS Number

[2361241-23-6]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/bi-749327.html

Purity

99.91

Solubility

DMSO : 31.25 mg/mL (ultrasonic)

Smiles

NC1=NN=C(C2CCN(C(C3=CC=C(OC4=CC=C(C(F)(F)F)C=C4)C=C3)=O)CC2)C=C1

Molecular Formula

C23H21F3N4O2

Molecular Weight

442.43

Precautions

H315, H319, H335

References & Citations

[1]Lin B L, et al. In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease. Proc Natl Acad Sci U S A. 2019 May 14;116 (20) :10156-10161.