PROTAC ERRα ligand 2
PROTAC ERRα ligand 2 is an estrogen-related receptor α (ERRα) inverse agonist with an IC50 of 5.67 nM. PROTAC ERRα ligand 2 (IC50=5.67 nM) displays a ~11-fold improved potency than XCT790 (IC50=61.3 nM) [1].
Product Specifications
CAS Number
2306388-57-6
UNSPSC
12352005
Hazard Statement
H302
Target
Estrogen Receptor/ERR; Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
PROTAC; Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-err-alpha-ligand-2.html
Purity
99.36
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
O=C(O)/C(C#N)=C/C1=CC(OC)=C(C=C1)OCC2=CC=C(C(F)(F)F)C=C2C(F)(F)F
Molecular Formula
C20H13F6NO4
Molecular Weight
445.31
Precautions
H302
References & Citations
[1]Peng L, et al. Identification of New Small-Molecule Inducers of Estrogen-related Receptor α (ERRα) Degradation. ACS Med Chem Lett. 2019 Apr 12;10 (5) :767-772.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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