PROTAC ERRα ligand 2

PROTAC ERRα ligand 2 is an estrogen-related receptor α (ERRα) inverse agonist with an IC50 of 5.67 nM. PROTAC ERRα ligand 2 (IC50=5.67 nM) displays a ~11-fold improved potency than XCT790 (IC50=61.3 nM) [1].

Product Specifications

CAS Number

[2306388-57-6]

UNSPSC

12352005

Hazard Statement

H302

Target

Estrogen Receptor/ERR; Ligands for Target Protein for PROTAC

Type

Reference compound

Related Pathways

PROTAC; Vitamin D Related/Nuclear Receptor

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-err-alpha-ligand-2.html

Purity

99.36

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

O=C(O)/C(C#N)=C/C1=CC(OC)=C(C=C1)OCC2=CC=C(C(F)(F)F)C=C2C(F)(F)F

Molecular Formula

C20H13F6NO4

Molecular Weight

445.31

Precautions

H302

References & Citations

[1]Peng L, et al. Identification of New Small-Molecule Inducers of Estrogen-related Receptor α (ERRα) Degradation. ACS Med Chem Lett. 2019 Apr 12;10 (5) :767-772.