INCB059872 (tosylate)
INCB059872 tosylate is a potent, selective and orally active lysine-specific demethylase 1 inhibitor. INCB059872 binds to and inhibits LSD1, enhancing H3K4 methylation, thereby increasing the expression of tumor suppressor genes. INCB059872 inhibition also promotes H3K9 methylation, thereby reducing the transcription of tumor-promoting genes[1].
Product Specifications
CAS Number
2081940-67-0
UNSPSC
12352005
Target
Histone Demethylase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/incb059872-tosylate.html
Smiles
OC(C1(CCC1)CN2CCC(COC)(CC2)CN[C@H]3[C@@](C4=CC=CC=C4)([H])C3)=O.O=S(O)(C5=CC=C(C=C5)C)=O
Molecular Formula
C30H42N2O6S
Molecular Weight
558.73
References & Citations
[1] Johnston G, et al. Nascent transcript and single-cell RNA-seq analysis defines the mechanism of action of the LSD1 inhibitor INCB059872 in myeloid leukemia. Gene. 2020;752:144758.|[2]LSD1/KDM1A inhibitors in clinical trials: advances and prospects
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
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