EIPA (hydrochloride)
EIPA (L593754) hydrochloride is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA hydrochloride also enhances autophagy by inhibiting Na+/H+-exchanger 3 (NHE3) . EIPA hydrochloride inhibits macropinocytosis as well. EIPA hydrochloride can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma[1][2][3][5].
Product Specifications
CAS Number
[1345839-28-2]
Product Name Alternative
L593754 (hydrochloride) ; MH 12-43 (hydrochloride) ; Ethylisopropylamiloride (hydrochloride)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; COX; Na+/H+ Exchanger (NHE) ; Prostaglandin Receptor; TRP Channel
Type
Reference compound
Related Pathways
Autophagy; GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/eipa-hydrochloride.html
Concentration
10mM
Purity
98.31
Solubility
DMSO : 130 mg/mL (ultrasonic)
Smiles
O=C(C1=NC(Cl)=C(N(CC)C(C)C)N=C1N)NC(N)=N.Cl
Molecular Formula
C11H19Cl2N7O
Molecular Weight
336.22
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-2
Citation 01
Available Sizes
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