FR-62765

FR-62765 is a derivative of WF-3681. FR-62765 can significantly inhibit the accumulation of sorbitol in the sciatic nerve and the decrease of motor nerve conduction velocity in the tail of diabetic neuropathy rats, which can be used in the research of diabetic neuropathy[1].

Product Specifications

CAS Number

[105346-34-7]

UNSPSC

12352005

Target

Aldose Reductase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/fr-62765.html

Smiles

O=C1OC(CCC(OCC)=O)C(C2=CC=CC=C2)=C1OC

Molecular Formula

C16H18O5

Molecular Weight

290.31

References & Citations

[1]Nishikawa M, et al. Studies on WF-3681, a novel aldose reductase inhibitor. IV. Effect of FR-62765, a derivative of WF-3681, on the diabetic neuropathy in rats. J Antibiot (Tokyo) . 1991 Apr;44 (4) :441-4.