Quinine (hemisulfate hydrate)

Quinine hemisulfate hydrate, an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine hemisulfate hydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV, with an IC50 of 169 μM[1][2].

Product Specifications

CAS Number

[207671-44-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Parasite; Potassium Channel

Type

Natural Products

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/quinine-hemisulfate-hydrate.html

Purity

99.42

Solubility

H2O : 4 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

[H][C@@]1([C@H](O)C2=CC=NC3=C2C=C(OC)C=C3)C[C@H]4[C@@H](C=C)C[N@@]1CC4.OS(O)(=O)=O.O.[1/2]

Molecular Formula

C20H24N2O2.1/2H2O4S.H2O

Molecular Weight

391.48

Precautions

H302, H315, H319, H335

References & Citations

[1]Jane Achan , et al. Quinine, an Old Anti-Malarial Drug in a Modern World: Role in the Treatment of Malaria. Malar J. 2011 May 24;10:144.|[2]Wrighton DC, et al. Mechanism of inhibition of mouse Slo3 (KCa 5.1) potassium channels by quinine, quinidine and barium. Br J Pharmacol. 2015 Sep;172 (17) :4355-63.