γ-secretase-IN-2
γ-secretase-IN-2 (Compound 34) is an inhibitor for γ-secretase, with an IC50 of 0.06 nM. γ-secretase-IN-2 can be used for the study of Alzheimer's disease[1].
Product Specifications
CAS Number
564462-36-8
UNSPSC
12352005
Target
γ-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/γ-secretase-in-2.html
Smiles
OC[C@@H](C1=CC(F)=C(F)C=C1)[C@@H](C2=CC=C(F)C=C2)C(N[C@H]3N=C(C4=CC=CC=C4)C5=CC=CC=C5NC3=O)=O
Molecular Formula
C31H24F3N3O3
Molecular Weight
543.54
References & Citations
[1]Churcher I, et al., Design and synthesis of highly potent benzodiazepine gamma-secretase inhibitors: preparation of (2S,3R) -3- (3,4-difluorophenyl) -2- (4-fluorophenyl) -4- hydroxy-N- ((3S) -1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]-diazepin-3-yl) butyramide by use of an asymmetric Ireland-Claisen rearrangement. J Med Chem. 2003 Jun 5;46 (12) :2275-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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