Human CCR4 Full Length Protein, Flag, His Tag (Detergent)
Human CCR4 Full Length Protein, Flag, His Tag (CC4-H52D3) is expressed from human 293 cells (HEK293) . It contains AA Asn 2 - Leu 360 (Accession # P51679-1) .
Product Specifications
Background
C-C chemokine receptor type 4 is a receptor for the following CC chemokines: CCL2, CCL4, CCL5, CCL17, CCL22, belongs to the G protein-coupled receptor family. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. CCR4 is often expressed on leukemic cells in cutaneous T-cell lymphoma (CTCL) . Mogamulizumab is a humanized monoclonal antibody targeted at CCR4and is an investigational drug for CTCL.
Specifications
This protein carries flag tag at the N-terminus and polyhistidine tag at the C-terminus. The protein has a calculated MW of 60.3 kDa.
Accession Number
P51679-1
Expression Region
Asn 2 - Leu 360
Host
HEK293
Target
CCR4
Conjugation
Unconjugated
Tag
N-Flag & C-10xHis
Source
Human
Stability
● The product MUST be stored at -70°C or lower upon receipt; ● -70°C for 3 months under sterile conditions.
Endotoxin
1.0 EU per μg
Purity
80%
Bioactivity
Immobilized Human CCR4 Full Length Protein, Flag,His Tag (Cat. No. CC4-H52D3) at 1 μg/mL (100 μL/well) can bind Anti-CCR4 Antibody, Human IgG1 with a linear range of 0.06-1 ng/mL (QC tested).
Format
Liquid
Buffer
50 mM HEPES, 150 mM NaCl, DDM, CHS, pH7.5
Additives
Glycerol
Molecular Weight
60.3 kDa
Shipping Conditions
Dry ice
Storage Conditions
-70°C
Package Size
20ug*1
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/CC4-H52D3.pdf
Species
Human
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