Human CCR4 Full Length Protein, Flag, His Tag (Detergent)

C-C chemokine receptor type 4 is a receptor for the following CC chemokines: CCL2, CCL4, CCL5, CCL17, CCL22, belongs to the G protein-coupled receptor family. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. CCR4 is often expressed on leukemic cells in cutaneous T-cell lymphoma (CTCL) . Mogamulizumab is a humanized monoclonal antibody targeted at CCR4and is an investigational drug for CTCL.

Product Specifications

Background

Specifications

This protein carries a flag tag at the N-terminus and a polyhistidine tag at the C-terminus. The protein has a calculated MW of 60.3 kDa.

Accession Number

P51679-1

Expression Region

Asn 2 - Leu 360

Host

HEK293

Target

CCR4

Conjugation

Unconjugated

Tag

N-Flag & C-10xHis

Source

Human

Stability

The product MUST be stored at -70°C or lower upon receipt; -70°C for 3 months under sterile conditions.

Endotoxin

1.0 EU per μg

Purity

80%

Bioactivity

Immobilized Human CCR4 Full Length Protein, Flag,His Tag (Cat. No. CC4-H52D3) at 1 μg/mL (100 μL/well) can bind Anti-CCR4 Antibody, Human IgG1 with a linear range of 0.06-1 ng/mL (QC tested).