TAS2940
TAS2940 is a brain-penetrable, orally active, irreversible and selective pan-ERBB inhibitor. TAS2940 against wild-type HER2, HER2 V777L, and A775_G776insYVMA with IC50 values of 5.6 nM, 2.1 nM, and 1.0 nM, respectively. TAS2940 can be used for the study of tumors with HER2 and EGFR aberrations[1].
Product Specifications
CAS Number
2451398-65-3
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tas2940.html
Smiles
NC1=NC=NC2=C1C(C(N[C@@H](C3=CC=CC=C3)C)=O)=C(C#CC4CC4)N2[C@@H]5C[C@H](C)N(C(C=C)=O)C5
Molecular Formula
C28H30N6O2
Molecular Weight
482.58
References & Citations
[1]Kei Oguchi, et al. TAS2940, a novel brain-penetrable pan-ERBB inhibitor, for tumors with HER2 and EGFR aberrations. Cancer Sci. 2023 Feb;114 (2) :654-664.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Frequently Asked Questions
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