ALDH1A1-IN-5

ALDH1A1-IN-5 (compound 25) is a potent aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitor with EC50 value of 83, 45, 43 µM for ALDH1A1, ALDH1A2, ALDH1A3, respectively. ALDH1A1-IN-5 has the potential for the research of high-grade serous ovarian cancer (HGSOC) [1].

Product Specifications

UNSPSC

12352005

Target

Aldehyde Dehydrogenase (ALDH)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/aldh1a1-in-5.html

Solubility

10 mM in DMSO

Smiles

OC1=C(C=CC=C1CNC2=NC3=CC(Cl)=CC=C3N2CC4COC4)Cl

Molecular Formula

C18H17Cl2N3O2

Molecular Weight

378.25

References & Citations

[1]Takahashi C, et al. Development of substituted benzimidazoles as inhibitors of human aldehyde dehydrogenase 1A isoenzymes. Chem Biol Interact. 2024 Mar 1;391:110910.